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ISER/BrightFocus 2017 Glaucoma Symposium

6:00am EDT

Registration Salons I-V Hallway

6:30am EDT

Breakfast Dining Room

7:00am EDT

Introduction Emory Amphitheater

7:15am EDT

Genetics and Epidemiology of Glaucoma Emory AmphitheaterJaney Wiggs MD PhD

8:10am EDT

Clinical Diagnosis (Including Functional and Imaging Technologies) and Management of Glaucoma Emory AmphitheaterArthur Sit MD

9:05am EDT

Anatomy, Biochemistry and Pathology of Aqueous Humor Outflow Emory AmphitheaterErnst Tamm MD

10:00am EDT

Break Amphitheater Break Area

10:20am EDT

Pharmacology and Physiology (Including Model Systems) of Aqueous Humor Outflow Emory AmphitheaterW. Daniel Stamer PhD

11:15am EDT

Pathophysiology of Glaucomatous Optic Nerve Damage in the Human and Non-Human Primate Emory AmphitheaterClaude Burgoyne MD

12:10pm EDT

Lunch Dining Room

1:00pm EDT

Experimental Outflow Obstruction to Study Pressure-Induced Optic Nerve Damage Emory AmphitheaterShandiz Tehrani MD PhD

1:55pm EDT

Inducible and Genetic Models of Glaucoma Emory AmphitheaterAbbot F. Clark PhD

2:50pm EDT

Quick Break Amphitheater Break Area

3:00pm EDT

Retinal Ganglion Cell Death in Glaucoma Emory AmphitheaterRobert W. Nickells PhD

4:15pm EDT

Platform Session I: Imaging, From Bench to Bedside Emory AmphitheaterJoel Schuman MD • Brian Samuels MD PhD

4:16pm EDT

LIVE IMAGING OF RETINAL PERICYTES: EVIDENCE FOR EARLY CALCIUM UPTAKE, CAPILLARY CONSTRICTION AND VASCULAR DYSREGULATION IN OCULAR HYPERTENSION GLAUCOMA Emory AmphitheaterLuis Alarcon-Martinez PhD

4:35pm EDT

SPECTRAL IMAGING OF THE HUMAN OPTIC NERVE HEAD CONNECTIVE TISSUE Emory AmphitheaterLaura Paletto BSc MSc

4:55pm EDT

THE LINK BETWEEN ACCOMMODATION PRESBYOPIA AND GLAUCOMA Emory AmphitheaterPaul L. Kaufman MD PhD

5:15pm EDT

EVIDENCE OF OPTIC NERVE HEAD RIM TISSUE COMPRESSION IN EARLY GLAUCOMA Emory AmphitheaterBrad Fortune OD PhD

5:35pm EDT

Keynote Lecture I: Glaucoma Imaging - What We See and What We Want to See Emory AmphitheaterLeopold Schmetterer PhD

6:30pm EDT

Welcome Reception Great Hearth

7:30pm EDT

Dinner Dining Room

6:30am EDT

Breakfast Dining Room

7:00am EDT

Registration Salons I-V Hallway

8:00am EDT

Keynote Lecture II: Imaging Retinal Ganglion Cells Emory AmphitheaterBalwantray Chauhan PhD

8:44am EDT

Platform Session II: Clinical and Translational Studies Emory AmphitheaterPaul L. Kaufman MD • Rachel Kuchtey PhD

8:45am EDT

LONG NOSES AND PROTECTIVE EYE SHIELDS BOTH REDUCE LIMBAL STRAIN VARIABILITY AND MAGNITUDE DURING SIMULATED SLEEP IN ADULTS WITH GLAUCOMA Emory AmphitheaterAlison Flatau PhD

9:05am EDT

RISK OF INDIRECT INGUINAL HERNIA (IIH) IS INCREASED IN MALE PATIENTS WITH EXFOLIATION SYNDROME: THE UTAH PROJECT ON EXFOLIATION SYNDROME (UPEXS) Emory AmphitheaterBrian M. Besch

9:25am EDT

NITRIC OXIDE SUPPLEMENTATION TO TREAT SEVERE GLAUCOMA IN A PATIENT WITH eNOS T-786C POLYMORPHISM Emory AmphitheaterSravanthi Vegunta MD

9:45am EDT

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS MODULATE TRANSFORMING GROWTH FACTOR BETA SIGNALING IN RETINA AND REDUCE IOP IN NORMAL MICE Emory AmphitheaterRalph J. Hazlewood II PhD

10:05am EDT

Break and Poster Viewing Salons III-V + Garden Overlook

10:30am EDT

Platform Session III: Hot Topics Emory AmphitheaterChristopher Girkin MD • Jeff Goldberg MD

10:31am EDT

RESPONSE OF THE TRILAMINAR RETINAL VESSEL NETWORK TO IOP ELEVATION IN RAT EYES Emory AmphitheaterBang V. Bui PhD

10:50am EDT

THE ROLE OF Wnt SIGNALING IN GLUCOCORTICOID-INDUCED GLAUCOMA Emory AmphitheaterWeiming Mao PhD

11:10am EDT

A NOVEL SMALL MOLECULE INHIBITS FIBROGENESIS IN HUMAN TRABECULAR MESHWORK CELLS Emory AmphitheaterChan Young Park PhD

11:30am EDT

ENHANCED LENTIVIRAL-MEDIATED GENE DELIVERY TO TM CELLS IN VITRO AND TM CELLS IN EYE ORGAN CULTURE Emory AmphitheaterCurtis R. Brandt PhD

11:50am EDT

INVESTIGATING THE MECHANISM OF EXTENDED IOP REDUCTION BY 9856i Emory AmphitheaterDarryl R. Overby PhD

12:10pm EDT

TRANSCRIPTIONAL REGULATION OF PRO-INFLAMMATORY CYTOKINES BY HIF-1α IN GLAUCOMA MODEL Emory AmphitheaterShahid Husain

12:30pm EDT

Lunch Dining Room

1:45pm EDT

Platform Session IV: Animal Models Emory AmphitheaterGillian McLellan PhD • Ted Acott PhD

1:46pm EDT

TESTING AND VALIDATION OF A NEW CEREBROSPINAL FLUID PRESSURE (CSFP) TELEMETRY SENSOR Emory AmphitheaterJ. Crawford Downs PhD

2:05pm EDT

ROUND-THE-CLOCK MEASUREMENT AND MANIPULATION OF IOP IN RATS Emory AmphitheaterChristopher L Passaglia PhD

2:25pm EDT

THE TREE SHREW MODEL OF GLAUCOMA Emory AmphitheaterBrian C. Samuels MD PhD

2:45pm EDT

OPTOGENETIC REGULATION OF EYE PRESSURE Emory AmphitheaterYang Sun MD PhD

3:05pm EDT

Break and Poster Viewing Salons III-V + Garden Overlook

3:35pm EDT

Platform Session V: Genetics Emory AmphitheaterYvonne Ou MD • Gareth Howell PhD

3:36pm EDT

PRESERVING AGING VASCULATURE IN THE OPTIC NERVE HEAD TO PREVENT GLAUCOMA Emory AmphitheaterRebecca A. Buchanan BS

3:55pm EDT

GENOMIC LOCUS MODULATING CORNEAL THICKNESS IN THE MOUSE IDENTIFIES POU6F2 AS A POTENTIAL RISK OF DEVELOPING GLAUCOMA Emory AmphitheaterEldon E. Geisert PhD

4:15pm EDT

DIGENIC AND PHYSICAL INTERACTION OF GENES IN PRIMARY CONGENITAL GLAUCOMA Emory AmphitheaterSubhabrata Chakrabarti PhD

4:35pm EDT

SYSTEMS GENETICS IDENTIFIES A ROLE FOR CACNA2D1 REGULATION IN ELEVATED INTRAOCULAR PRESSURE AND GLAUCOMA SUSCEPTIBILITY Emory AmphitheaterMonica M. Jablonski PhD FARVO

4:55pm EDT

UPREGULATION OF MYOCILIN EXPRESSION IN Pro370Leu MYOCILIN MUTANT TM CELLS USING GENOME EDITING Emory AmphitheaterXinbo Li PhD

5:15pm EDT

MYOCILIN STRUCTURE AND MISFOLDING Emory AmphitheaterRaquel L. Lieberman PhD

5:35pm EDT

Keynote Lecture III: Primary Open-Angle Glaucoma Genetics: Insights into a Complex Disease Emory AmphitheaterJaney Wiggs MD PhD

6:30pm EDT

Poster Reception Salons III-V + Garden Overlook

7:30pm EDT

Dinner Dining Room

7:00am EDT

Breakfast Dining Room Registration Salons I-V Hallway

8:00am EDT

Keynote Lecture IV: Aqueous Humor Outflow and Beyond - Failure of Molecular Homeostasis in Glaucoma Emory AmphitheaterErnst Tamm MD

8:45am EDT

Platform Session VI: Young Investigators Emory AmphitheaterTatjana Jakobs MD • Jeremy Sivak PhD

8:46am EDT

THE BAX ACTIVATION MECHANISM REMAINS ACTIVE IN THE RGCs OF BAX DEFICIENT MICE FOR SEVERAL MONTHS FOLLOWING OPTIC NERVE CRUSH Emory AmphitheaterRyan J. Donahue

9:01am EDT

DIFFERENTIALLY EXPRESSED microRNAs IN THE AQUEOUS HUMOR OF PATIENTS WITH EXFOLIATION GLAUCOMA OR PRIMARY OPEN-ANGLE GLAUCOMA Emory AmphitheaterMichelle D. Drewry

9:17am EDT

REPETITIVE STRESS AND STRAIN DURING A CONTROLLED ELEVATION OF IOP INCREASES RETINAL GANGLION CELL DYSFUNCTION AND OPTIC NERVE INJURY Emory AmphitheaterHari Jayaram MA BMBCh PhD FRCSEd

9:33am EDT

INDUCIBLE MMP-3 EXPRESSION IN A STEROID-INDUCED MURINE MODEL OF GLAUCOMA Emory AmphitheaterJeffrey O'Callaghan BA

9:49am EDT

IMPAIRED CEREBROSPINAL FLUID FLOW INTO THE OPTIC NERVE IN GLAUCOMA Emory AmphitheaterEmily Mathieu BSc

10:05am EDT

Break and Poster Viewing Salons III-V + Garden Overlook

10:30am EDT

Platform Session VII: Glia Emory AmphitheaterMonica Vetter PhD • Yang Hu PhD

10:31am EDT

LINKING IOP ELEVATION TO INFLAMMATION THROUGH ATP Emory AmphitheaterClaire Mitchell PhD

10:50am EDT

MYELIN-RELATED PROTEIN ALTERATIONS IN THE OPTIC NERVE HEAD (ONH) OF NON-HUMAN PRIMATES (NHP) WITH EARLY EXPERIMENTAL GLAUCOMA (EEG) Emory AmphitheaterCheri Stowell PhD

11:10am EDT

DO MICROGLIA ENGULF 'LIVING' NEURONS? Emory AmphitheaterFelix Vazquez-Chona

11:30am EDT

FUNCTIONAL ROLE OF cAMP IN OXIDATIVE STRESS-INDUCED OPTIC NERVE HEAD ASTROCYTES Emory AmphitheaterWon-Kyu Ju

11:50am EDT

ASTROCYTE-PRODUCED LIPID MEDIATORS LXA4 and LXB4 PROTECT RETINAL GANGLION CELLS FROM ACUTE AND CHRONIC INJURY Emory AmphitheaterJeremy M. Sivak PhD

12:10pm EDT

DEBRIS IN THE OPTIC NERVE IN MOUSE DEVELOPMENT AND GLAUCOMA Emory AmphitheaterNicholas Marsh-Armstrong PhD

12:30pm EDT

Lunch Dining Room

1:45pm EDT

Platform Session VIII: Neurodegeneration Emory AmphitheaterClaire Mitchell PhD • Colleen McDowell PhD

1:46pm EDT

TARGETING THE FAS RECEPTOR IN A MOUSE MODEL OF GLAUCOMA PROVIDES SIGNIFICANT NEUROPROTECTION VIA INHIBITION OF INFLAMMATION AND APOPTOSIS Emory AmphitheaterAnitha Krishnan PhD

2:05pm EDT

OPTIC NERVE INJURY-INDUCED ER STRESS AND NEURODEGENERATION IN OPTIC NEUROPATHIES Emory AmphitheaterYang Hu MD PhD

2:25pm EDT

COMBINED DEFICIENCY OF JUN AND DDIT3 (CHOP) PROVIDE ADDITIVE, NEAR COMPLETE PROTECTION TO RETINAL GANGLION CELLS AFTER OPTIC NERVE INJURY Emory AmphitheaterRichard T. Libby PhD

2:45pm EDT

KINETICS OF BAX RECRUITMENT IN RGCS AFTER OPTIC NERVE DAMAGE Emory AmphitheaterRobert W. Nickells PhD

3:05pm EDT

IDENTIFICATION OF GSK-3 AND MAP4K4 FAMILY MEMBERS AS MEDIATORS OF PRIMARY RGC CELL DEATH Emory AmphitheaterDerek S. Welsbie MD PhD

3:25pm EDT

AUTOPHAGY IN THE NEURORETINA AND ANGLE REGIONA OF DBA/2J MICE Emory AmphitheaterPaloma B. Liton PhD

3:45pm EDT

Break and Poster Viewing Salons III-V + Garden Overlook

4:15pm EDT

Platform Session IX: Biomechanics Emory AmphitheaterClaude Burgoyne MD • Ian Sigal PhD

4:16pm EDT

IRIS IS MECHANICALLY STIFFER IN PATIENTS WITH OCCLUDABLE ANGLES POST LASER PERIPHERAL IRIDOTOMY Emory AmphitheaterRouzbeh Amini PhD

4:35pm EDT

BIOMECHANICS OF THE OPTIC NERVE HEAD OF HUMAN AND MOUSE EYES Emory AmphitheaterThao D. Nguyen PhD

4:55pm EDT

INCORPORATING PRE-EXISTING STRESS AND REALISTIC ANISOTROPIC MATERIAL PROPERTIES INTO EYE-SPECIFIC MODELS OF THE HUMAN OPTIC NERVE HEAD Emory AmphitheaterRafael Grytz PhD

5:15pm EDT

DIFFERENTIAL MIRNA AND MRNA EXPRESSION IN RESPONSE TO MECHANICAL STRAIN IN PRIMARY HUMAN TRABECULAR MESHWORK CELLS Emory AmphitheaterYutao Liu MD PhD

5:35pm EDT

Keynote Lecture V: High 'TEK' Solutions for Glaucoma Emory AmphitheaterSusan E. Quaggin MD

6:30pm EDT

Awards Reception and Gala Dinner Salons I-III

7:30pm EDT

Dinner Dining Room

7:00am EDT

Breakfast Dining Room Registration Salons I-V Hallway

8:00am EDT

Platform Session X: Pharmacology Emory AmphitheaterDarryl Overby PhD • Paloma Liton PhD

8:01am EDT

TRPV4 CHANNELS ACT AS A CONTROL SWITCH FOR HEMICHANNEL OPENING AND AUTOCRINE REGULATION OF NPE FUNCTION Emory AmphitheaterNick Delamere PhD

8:20am EDT

TADALAFIL TREATMENT ATTENUATES RETINOPATHY IN ANIMAL MODELS OF PRIMARY OPEN ANGLE GLAUCOMA Emory AmphitheaterLauren Katie Wareham PhD

8:40am EDT

EFFECT OF CKLP1 ON AQUEOUS HUMOR DYNAMICS AND FEASIBILITY OF COMBINATION TREATMENT WITH EXISTING OCULAR HYPOTENSION MEDICATIONS Emory AmphitheaterUttio Roy Chowdhury PhD

9:00am EDT

INTERLEUKIN-20 (IL20) SIGNALING IN TRABECULAR MESHWORK (TM) CELLS AND THE EFFECTS ON OUTFLOW RATES IN PERFUSION CULTURE Emory AmphitheaterMary K. Wirtz PhD

9:20am EDT

FUNCTION OF CAV1/CAVEOLAE AS MECHANOSENSORS/MECHANOPROTECTORS IN THE CONVENTIONAL OUTFLOW PATHWAY Emory AmphitheaterMichael H. Elliott PhD

9:40am EDT

IMPROVING DRUG DELIVERY TO THE TRABECULAR MESHWORK DURING MOUSE EYE PERFUSIONS Emory AmphitheaterJoseph M. Sherwood PhD

10:00am EDT

Break and Poster Viewing Amphitheater Break Area

10:30am EDT

Platform Session XI: Regeneration Emory AmphitheaterDerek S. Welsbie MD PhD • Ian Pitha MD PhD

10:31am EDT

GENE THERAPY OF THE TRABECULAR MESHWORK (TM) BY ADENO-ASSOCIATED VIRUS (AAV): LONG-TERM STABLE TRANSGENE EXPRESSION AND INTRAOCULAR PRESSURE (IOP) CONTROL Emory AmphitheaterAndrás M. Komáromy DrMedVet PhD

10:50am EDT

ENHANCED MESENCHYMAL STEM CELL DELIVERY TO THE TRABECULAR MESHWORK USING MAGNETIC NANOPARTICLES Emory AmphitheaterC. Ross Ethier PhD

11:10am EDT

MECHANISMS OF STEM CELL HOMING AND EXTRACELLULAR MATRIX DEGRADATION FOR TRABECULAR MESHWORK REGNERATION Emory AmphitheaterYiqin Du MD PhD

11:30am EDT

GENOMIC MODULATION OF OPTIC NERVE REGENERATION IN MICE Emory AmphitheaterJiaxing Wang

11:50am EDT

TRANSPLANTATION OF iPSC-DERIVED RETINAL GANGLION CELLS INTO MOUSE MODELS OF GLAUCOMA Emory AmphitheaterJulia Oswald PhD

12:10pm EDT

Keynote Lecture VI: High Content Screening Approaches to Identify Novel Neuroprotective Agents for Glaucoma Emory AmphitheaterDon Zack MD PhD

12:55pm EDT

Lunch Dining Room